An accidental needle stick occurs during the routine treatment of an HIV-positive patient who arrives at your clinic. Immediate administration of _______________ can block viral entry.
a. Enfuvirtide
b. Vapendavir
c. AZT
d. Amantadine

검증된 단계별 안내

Step 1: Understand the context of the problem, which involves an accidental needle stick exposure to HIV, a virus that infects host cells by entering them.

Step 2: Recall that blocking viral entry means preventing the virus from fusing with or penetrating the host cell membrane, which stops infection at the earliest stage.

Step 3: Review the mechanisms of the drugs listed: enfuvirtide is a fusion inhibitor that blocks HIV from entering cells; vapendavir targets rhinoviruses; AZT is a reverse transcriptase inhibitor acting after viral entry; amantadine blocks influenza virus uncoating.

Step 4: Identify that the drug effective in blocking HIV viral entry immediately after exposure is enfuvirtide, as it specifically inhibits the fusion of HIV with the host cell membrane.

Step 5: Conclude that immediate administration of enfuvirtide can block viral entry in this scenario.

비슷한 문제에 대한 검증된 영상 답변:

이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.

영상 길이:

주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

HIV Viral Entry Mechanism

HIV enters host cells by binding its envelope glycoproteins to CD4 receptors and co-receptors on the cell surface, followed by fusion of the viral and cellular membranes. Blocking this entry step prevents the virus from infecting new cells, which is critical in early intervention after exposure.

Enfuvirtide as an Entry Inhibitor

Enfuvirtide is a fusion inhibitor that binds to the HIV gp41 protein, preventing the conformational changes needed for viral fusion with the host cell membrane. It is used to block HIV entry into cells, making it effective for post-exposure prophylaxis immediately after potential exposure.

Post-Exposure Prophylaxis (PEP) for HIV

PEP involves administering antiretroviral drugs soon after potential HIV exposure to prevent infection. Drugs that block viral entry, like enfuvirtide, are crucial in the initial phase, while reverse transcriptase inhibitors like AZT act later in the viral replication cycle.

An accidental needle stick occurs during the routine treatment of an HIV-positive patient who arrives at your clinic. Immediate administration of _______________ can block viral entry.a. Enfuvirtideb. Vapendavirc. AZTd. Amantadine