In a typical nucleophilic substitution reaction, what type of bond cleavage occurs when the leaving group departs from the substrate?

Which of the following alkyl halides reacts fastest with trimethylamine in an $S_{\mathrm{N\; 2}}$ reaction?

Which of the following is a substitution reaction?

Which of the following alkyl halides is the most reactive substrate in an $E_2$ reaction?

Which of the following is the best nucleophile in ${\mathrm{CH}}_3\mathrm{OH}$ (methanol) solvent?

Which of the following alkyl halides would react the fastest with $-\mathrm{OH}$ in an E2 reaction?

Which of the following alkyl halides is most likely to undergo solvolysis via an $S{N}_1$ mechanism?

Which of the following alkyl halides would be most reactive in an $S{N}_2$ reaction?

In the context of nucleophilic substitution, what is the major organic product obtained when ${\mathrm{CH}}_3\mathrm{Br}$ reacts with aqueous $\mathrm{NaOH}$ under standard conditions?