미해결 질문
Provide the product created when phenol reacts with the following reagents.
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20. Phenols
Kolbe-Schmidt Reaction
객관식
Supply the reagents necessary to accomplish the following transformation.
A
1. CH3CH2NHCH3 xs
2. NaBH4/H3O+
B
1. SOCl2
2. CH3CH2NHCH3 xs
3. LiAlH4 xs/H3O+
C
1. LiAlH4 xs/H3O+
2. PCC/CH2Cl2
3. CH3CH2NHCH3 xs
D
1. CH3OH/H3O+
2. CH3CH2NHCH3 xs
3. DIBAH/H2O
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검증된 단계별 안내1
Identify the functional groups in the starting material and the product. The starting material is a carboxylic acid, and the product is an amine with an alcohol group.
Recognize that the transformation involves converting a carboxylic acid to an amine. This typically requires reduction of the carboxylic acid to an aldehyde or alcohol, followed by amination.
Consider using SOCl2 to convert the carboxylic acid to an acyl chloride, which is more reactive and can be reduced more easily.
Use LiAlH4, a strong reducing agent, to reduce the acyl chloride to an aldehyde or directly to an alcohol.
Finally, perform reductive amination using CH3CH2NHCH3 in excess to introduce the ethylmethylamine group, completing the transformation to the desired product.
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