객관식
Provide the major product and the correct mechanism for the following reaction.
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- 1. A Review of General Chemistry6h 57m
- Orgo 1: Pre-Course Review25m
- What is Organic Chemistry?10m
- Atomic Structure24m
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- 19. Reactions of Aromatics: EAS and Beyond5h 11m
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- 23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
- 24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 50m
- Tautomerization9m
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- 26. Amines1h 43m
- 27. Heterocycles2h 0m
- Nomenclature of Heterocycles15m
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- Reactions of Pyrrole, Furan, and Thiophene13m
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- 28. Carbohydrates5h 54m
- Monosaccharide20m
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- 29. Amino Acids4h 16m
- Proteins and Amino Acids19m
- L and D Amino Acids14m
- Polar Amino Acids14m
- Amino Acid Chart1h 14m
- Acid-Base Properties of Amino Acids33m
- Isoelectric Point14m
- Amino Acid Synthesis: HVZ Method12m
- Synthesis of Amino Acids: Acetamidomalonic Ester Synthesis16m
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- Synthesis of Amino Acids: Strecker Synthesis13m
- Reactions of Amino Acids: Esterification7m
- Reactions of Amino Acids: Acylation3m
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- 30. Peptides and Proteins2h 42m
- Peptides12m
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- Merrifield Solid-Phase Peptide Synthesis18m
- 31. Catalysis in Organic Reactions1h 30m
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- 33. The Organic Chemistry of Metabolic Pathways2h 52m
- Intro to Metabolism6m
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- Intro to Citric Acid Cycle7m
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- 34. Nucleic Acids1h 32m
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- Electron Configuration of Elements45m
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- 36. Synthetic Polymers1h 49m
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- Polymers Structure and Properties8m
19. Reactions of Aromatics: EAS and Beyond
Limitations of Friedel-Crafts Alkyation
객관식
Provide the major product and the correct mechanism for the following reaction.
A
B
C
D
10 댓글
검증된 단계별 안내1
Identify the type of reaction: The reaction involves benzene and an alkyl chloride in the presence of AlCl3, indicating a Friedel-Crafts alkylation.
Generate the electrophile: The AlCl3 acts as a Lewis acid and coordinates with the chlorine atom of the alkyl chloride, forming a carbocation intermediate.
Consider carbocation rearrangement: The initially formed carbocation may rearrange to a more stable carbocation if possible. In this case, a hydride shift can occur to form a more stable tertiary carbocation.
Attack of the benzene ring: The benzene ring acts as a nucleophile and attacks the carbocation, forming a sigma complex (arenium ion).
Regenerate aromaticity: The sigma complex loses a proton to regenerate the aromatic system, resulting in the alkylated benzene as the major product.
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