교과서 질문
Draw the following amino acids in all possible protonation states as you move from high pH to low pH.
b. His
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29. Amino Acids
Acid-Base Properties of Amino Acids
객관식
Calculate the pI for arginine (the pKa values—or the pKa values for the conjugate acids of bases—are given).
A
10.76
B
7.33
C
7.90
D
5.61
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검증된 단계별 안내1
Identify the ionizable groups in arginine: the carboxyl group (pKa = 2.17), the alpha-amino group (pKa = 9.04), and the guanidino group (pKa = 12.48).
Determine the charge of arginine at low pH: all groups are protonated, resulting in a +2 charge.
As the pH increases, the carboxyl group deprotonates first (pKa = 2.17), resulting in a +1 charge.
Continue increasing the pH until the next group deprotonates: the alpha-amino group (pKa = 9.04), resulting in a neutral charge.
Calculate the isoelectric point (pI) by averaging the pKa values of the groups that result in a neutral charge: (9.04 + 12.48) / 2.
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