Organic Chemistry
What is a primary advantage of Friedel-Crafts acylation over alkylation?
Why are acylation reactions not prone to carbocation rearrangements?
Predict the product of benzene reacting with acetyl chloride and AlCl3, and explain the stability of the intermediate.
In a reaction where polysubstitution is a concern, what adjustment can be made to the reactants to favor monosubstitution?
Design a synthetic route to obtain n-butylbenzene starting from benzene, comparing the outcomes of direct alkylation versus acylation followed by Clemensine reduction.
