Predict the product of the Claisen reactions shown.
(c)

검증된 단계별 안내

Identify the reactants involved in the Claisen reaction. Typically, a Claisen condensation involves two ester molecules or an ester and a ketone.

Determine the base used in the reaction. Commonly, a strong base like sodium ethoxide (NaOEt) is used to deprotonate the alpha hydrogen of the ester.

Recognize the formation of the enolate ion. The base abstracts an alpha hydrogen from the ester, forming an enolate ion, which is a key intermediate in the Claisen condensation.

Consider the nucleophilic attack. The enolate ion acts as a nucleophile and attacks the carbonyl carbon of another ester molecule, leading to the formation of a tetrahedral intermediate.

Identify the final product. The tetrahedral intermediate collapses, resulting in the elimination of an alkoxide ion and forming a β-keto ester as the final product of the Claisen condensation.

비슷한 문제에 대한 검증된 영상 답변:

이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.

영상 길이:

15m

주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Claisen Condensation

Claisen condensation is a reaction where two esters or one ester and a ketone react in the presence of a strong base to form a β-keto ester or a β-diketone. The reaction involves the formation of an enolate ion from one of the ester molecules, which then attacks the carbonyl carbon of another ester, leading to the formation of a new carbon-carbon bond.

Enolate Ion Formation

Enolate ions are formed when a strong base deprotonates the α-hydrogen of an ester or ketone, resulting in a resonance-stabilized anion. This ion is nucleophilic and can attack electrophilic centers, such as the carbonyl carbon in Claisen condensation, facilitating the formation of new carbon-carbon bonds.

Product Prediction in Claisen Reaction

Predicting the product of a Claisen reaction involves identifying the nucleophilic enolate ion and the electrophilic carbonyl carbon. The enolate ion attacks the carbonyl carbon, forming a new C-C bond and resulting in a β-keto ester or β-diketone. Understanding the structure of reactants and the mechanism helps in predicting the final product accurately.

Predict the product of the Claisen reactions shown. (c)