Bioprocess Engineering: Basic Concepts, 3rd edition

  • Michael L. Shuler, 
  • Fikret Kargi, 
  • Matthew DeLisa

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Overview

The Leading Introduction to Biochemical and Bioprocess Engineering, Updated with Key Advances in Productivity, Innovation, and Safety

 

Bioprocess Engineering, Third Edition, is an extensive update of the world’s leading introductory textbook on biochemical and bioprocess engineering and reflects key advances in productivity, innovation, and safety.

 

The authors review relevant fundamentals of biochemistry, microbiology, and molecular biology, including enzymes, cell functions and growth, major metabolic pathways, alteration of cellular information, and other key topics. They then introduce evolving biological tools for manipulating cell biology more effectively and to reduce costs of bioprocesses.

 

This edition presents major advances in the production of biologicals; highly productive techniques for making heterologous proteins; new commercial applications for both animal and plant cell cultures; key improvements in recombinant DNA microbe engineering; techniques for more consistent authentic post-translational processing of proteins; and other advanced topics. It includes new, improved, or expanded coverage of

  • The role of small RNAs as regulators
  • Transcription, translation, regulation, and differences between prokaryotes and eukaryotes
  • Cell-free processes, metabolic engineering, and protein engineering
  • Biofuels and energy, including coordinated enzyme systems, mixed-inhibition and enzyme-activation kinetics, and two-phase enzymatic reactions
  • Synthetic biology
  • The growing role of genomics and epigenomics Population balances and the Gompetz equation for batch growth and product formation
  • Microreactors for scale-up/scale-down, including rapid scale-up of vaccine production
  • The development of single-use technology in bioprocesses
  • Stem cell technology and utilization
  • Use of microfabrication, nanobiotechnology, and 3D printing techniques
  • Advances in animal and plant cell biotechnology

The text makes extensive use of illustrations, examples, and problems, and contains references for further reading as well as a detailed appendix describing traditional bioprocesses.

 

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Published by Pearson (July 6th 2021) - Copyright © 2017

ISBN-13: 9780137459469

Subject: Information Technology

Category: Computer Concepts & Applications

Table of contents

  • Part I: The Basics of Biology: An Engineer’s Perspective
  • Chapter 1: What Is a Bioprocess Engineer?
  • Chapter 2: An Overview of Biological Basics
  • Chapter 3: Enzymes
  • Chapter 4: How Cells Work
  • Chapter 5: Major Metabolic Pathways
  • Chapter 6: How Cells Grow
  • Chapter 7: Stoichiometry of Microbial Growth and Product Formation
  • Chapter 8: How Cellular Information Is Altered
  • Part II: Engineering Principles for Bioprocesses
  • Chapter 9: Operating Considerations for Bioreactors for Suspension and Immobilized Cultures
  • Chapter 10: Selection, Scale-Up, Operation, and Control of Bioreactors
  • Chapter 11: Recovery and Purification of Products
  • Chapter 12: Bioprocess Considerations in Using Animal Cell Cultures
  • Chapter 13: Bioprocess Considerations in Using Plant Cell Cultures
  • Chapter 14: Utilizing Genetically Engineered Organisms
  • Chapter 15: Medical Applications of Bioprocess Engineering
  • Chapter 16: Multiple Species in Culture
  • Appendix A: Traditional Industrial Bioprocesses

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