How does hemoglobin's affinity for oxygen change with varying concentrations of carbon dioxide?

• A. Carbon dioxide concentration has no effect on hemoglobin's affinity for oxygen.
• B. Increased carbon dioxide decreases hemoglobin's affinity for oxygen, facilitating oxygen release in tissues.
• C. Decreased carbon dioxide decreases hemoglobin's affinity for oxygen, enhancing oxygen uptake in the lungs.
• D. Increased carbon dioxide increases hemoglobin's affinity for oxygen, inhibiting oxygen release.

Answer: (B)