How does the cellular location of PRRs influence their ability to detect MAMPs and DAMPs?

• A. PRRs are not influenced by their cellular location for detection.
• B. PRRs on the cell surface detect extracellular MAMPs, while those inside cells detect intracellular MAMPs and DAMPs.
• C. Only endosomal PRRs detect DAMPs.
• D. All PRRs detect only extracellular MAMPs regardless of their location.

Answer: (B)