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Anatomy & Physiology: Digestive System Key Concepts

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  • Receptive relaxation in the stomach

    Receptive relaxation occurs in the fundus and body of the stomach, involving anticipation and response to food, controlled by the vagus nerve.

  • Adaptive relaxation of the stomach

    Adaptive relaxation refers to the stomach's ability to dilate to accommodate incoming food without increasing pressure.

  • Stress relaxation in stomach smooth muscle

    Stress relaxation is the stretching of stomach smooth muscle without increasing tension, allowing the stomach to expand.

  • Function of pacesetter cells in the digestive tract

    Pacesetter cells generate rhythmic waves of depolarization and repolarization, setting the rate of smooth muscle contractions but not initiating them.

  • Factors affecting rate of stomach emptying

    Rate depends on stomach processes and duodenal contents; larger meals and more liquid increase emptying speed.

  • Small intestine blood supply and innervation

    Receives blood from superior mesenteric artery, parasympathetic innervation from vagus nerve, and sympathetic innervation from long splanchnic nerves.

  • Role of hepatic portal vein

    Transports nutrient-rich blood from the small intestine to the liver for processing.

  • Characteristics of the duodenum

    Shortest small intestine segment (~25 cm), receives chyme, bile, and pancreatic enzymes; has few circular folds and small villi.

  • Function of the hepatopancreatic ampulla

    Site where the pancreatic duct and bile duct join and empty their contents into the duodenum.

  • Jejunum features and function

    Middle small intestine segment (~2.5 m) with prominent circular folds and villi; primary site of nutrient absorption.

  • Ileum characteristics

    Last small intestine segment (~1.5 m), absorbs vitamins and remaining nutrients; circular folds and villi decrease distally; terminal ileum lacks folds.

  • Plicae circulares

    Permanent circular folds in the small intestine that increase surface area for absorption, especially in the proximal part.

  • Villi and microvilli function

    Villi increase surface area and are made of enterocytes; microvilli are on enterocyte surfaces, further increasing absorption area.

  • Brush border enzymes roles

    Complete final digestion of carbohydrates and proteins; activate trypsinogen into trypsin.

  • Lacteal function in the small intestine

    Transports materials like protein-lipid packages that cannot enter capillaries, aiding fat absorption.

  • Duodenal glands secretion

    Secrete mucus with bicarbonate to neutralize chyme pH and release enterocrinin; located in submucosa and stimulated parasympathetically.

  • Secretin function

    Hormone secreted to neutralize acidic chyme entering the duodenum.

  • Cholecystokinin (CCK) role

    Released in response to fat or protein; stimulates gallbladder to release bile for fat digestion.

  • Pancreatic alpha-amylase function

    Enzyme that breaks down starch into simpler sugars.

  • Proteolytic enzymes from pancreas

    Secreted as inactive proenzymes; include protease (break large proteins) and peptidase (break peptides into amino acids).

  • Trypsin role in enzyme activation

    Activates other pancreatic proenzymes like chymotrypsinogen, procarboxypeptidase, and proelastase into active forms.

  • Liver lobes and hepatocytes

    Liver has four lobes (left, right, caudate, quadrate); hepatocytes detoxify, produce bile, and process nutrients.

  • Bile flow pathway in liver

    Bile produced by hepatocytes flows into bile canaliculi, then bile ductules, bile ducts, and finally the common bile duct.

  • Liver functions

    Metabolic regulation (nutrient storage/removal), hematological regulation (bile production), and bile secretion.

  • Emulsification

    Process where bile salts break down lipids into smaller droplets to increase surface area for enzyme action.

  • Gallbladder bile release trigger

    Release of CCK by the duodenum stimulates the gallbladder to release bile for fat digestion.

  • Large intestine functions

    Stores waste, absorbs water, and synthesizes vitamins K, B, and biotin.

  • Colon structural features

    Contains teniae coli (smooth muscle bands), haustra (pouches for expansion), and omental appendices (fat sacs).

  • Anal sphincters

    Internal anal sphincter is involuntary smooth muscle; external anal sphincter is voluntary skeletal muscle.

  • Composition of feces

    Approximately 75% water, 5% bacteria, and 20% indigestible material.

  • Age-related digestive system changes

    Decline in epithelial stem cell division, decreased smooth muscle tone causing constipation, loss of teeth, and increased cancer risk.