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Cellular Transport - Anatomy & Physiology

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  • What is passive transport?

    Passive transport is the movement of particles from a region of high concentration to low concentration without requiring ATP.

  • What determines the permeability of the plasma membrane in diffusion?

    Permeability depends on whether the membrane is freely permeable (any substance can pass), impermeable (nothing can pass), or selectively permeable (allows some substances but restricts others).

  • Define selectively permeable membrane.

    A membrane that allows the free passage of some molecules but restricts the passage of others based on size, charge, shape, and lipid solubility.

  • What factors influence diffusion?

    Distance to move, molecule size (smaller is faster), temperature (more heat increases motion), concentration gradient, and electrical forces (opposites attract, likes repel).

  • What types of diffusion occur across plasma membranes?

    Simple diffusion for lipid-soluble compounds and dissolved gases; channel-mediated diffusion for water-soluble compounds and ions.

  • What is facilitated diffusion?

    A passive process where carrier proteins transport molecules too large to pass through channels, such as glucose and amino acids.

  • What is active transport?

    Transport that requires ATP to move substances against their concentration gradient, often via carrier proteins like the Na+/K+ pump.

  • What is osmosis?

    Osmosis is the diffusion of water across a selectively permeable membrane toward a solution with a higher solute concentration.

  • What conditions must be met for osmosis to occur?

    Membrane must be freely permeable to water but selectively permeable to solutes; water moves toward the side with more solutes, increasing volume there.

  • What is osmotic pressure?

    Osmotic pressure is the force of a concentration gradient of water, equal to the hydrostatic pressure needed to stop osmosis.

  • What happens to a cell in a hypotonic solution?

    The cell gains water, swells, and may rupture (hemolysis in red blood cells).

  • What happens to a cell in a hypertonic solution?

    The cell loses water, shrinks, and becomes crenated.

  • What is the primary component responsible for the plasma membrane's barrier function?

    The phospholipid bilayer forms the physical barrier between the cell's internal and external environments.

  • How does the sodium-potassium pump work?

    It actively transports 3 Na+ ions out of the cell and 2 K+ ions into the cell using 1 ATP molecule, maintaining voltage and cell volume.

  • What is the difference between simple diffusion and facilitated diffusion?

    Simple diffusion moves small lipid-soluble molecules directly through the membrane; facilitated diffusion uses carrier proteins for larger or water-soluble molecules.

  • What restricts movement through a selectively permeable membrane?

    Size, electrical charge, molecular shape, and lipid solubility determine what can pass through.

  • What is the concentration gradient?

    The difference in solute concentration between two areas, driving diffusion from high to low concentration.

  • What is the role of channel proteins in diffusion?

    Channel proteins facilitate the movement of small water-soluble molecules and ions across the plasma membrane.

  • What is the significance of leak channels?

    Leak channels allow passive movement of ions like K+ across the membrane, contributing to membrane potential.

  • Why is osmosis considered a special case of diffusion?

    Because it specifically involves the movement of water molecules across a selectively permeable membrane, driven by solute concentration differences.