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Digestive System and Metabolism - Anatomy & Physiology

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  • Functions of the digestive system

    The digestive system is responsible for ingestion, digestion, absorption of nutrients, and elimination of waste.

  • Organs of the digestive system

    Main organs include the mouth, esophagus, stomach, small intestine, large intestine, rectum, and anus.

  • Accessory organs of the digestive system

    Accessory organs include the salivary glands, liver, gallbladder, and pancreas, which aid digestion.

  • Hormones of the digestive system

    Key hormones include gastrin, secretin, cholecystokinin (CCK), and gastric inhibitory peptide (GIP).

  • Cells of the stomach

    Include parietal cells (secrete HCl), chief cells (secrete pepsinogen), and mucous cells (secrete mucus).

  • Nervous system regulation of the digestive system

    Includes the enteric nervous system and autonomic control via parasympathetic and sympathetic inputs.

  • Motility in the digestive system

    Refers to muscle contractions like peristalsis and segmentation that move and mix food.

  • Microscopic anatomy of the small intestine

    Features villi and microvilli to increase surface area for nutrient absorption.

  • Normal flora of the large intestine

    Commensal bacteria that aid in fermentation, vitamin synthesis, and immune function.

  • Defecation reflex

    A spinal reflex triggered by rectal distension causing internal and external anal sphincter relaxation and defecation.

  • Hepatocytes

    Liver cells responsible for metabolism, bile production, detoxification, and storage.

  • Salivary glands

    Produce saliva containing amylase to begin carbohydrate digestion and lubricate food.

  • DNES cells

    Diffuse neuroendocrine system cells that secrete hormones regulating digestion and motility.

  • Metabolism

    All chemical reactions in the body, including catabolism (breakdown) and anabolism (synthesis).

  • Catabolism and anabolism

    Catabolism breaks down molecules to release energy; anabolism uses energy to build molecules.

  • Nutrient monomers that generate ATP

    Include glucose, fatty acids, and amino acids.

  • Protein catabolism

    Breakdown of proteins into amino acids for energy or synthesis.

  • Glucose catabolism

    Process of breaking down glucose to produce ATP via glycolysis, citric acid cycle, and electron transport chain.

  • Endergonic reactions

    Reactions that require energy input to proceed.

  • Phosphorylation

    Addition of a phosphate group to a molecule, often to activate or store energy.

  • Substrate level phosphorylation

    Direct transfer of a phosphate group to ADP to form ATP during glycolysis and the citric acid cycle.

  • Oxidation-reduction reactions

    Reactions involving the transfer of electrons between molecules, key in energy production.

  • Glycolysis: location, requirements, products

    Occurs in the cytoplasm, requires glucose and NAD+, produces pyruvate, ATP, and NADH.

  • Citric acid cycle: location, requirements, products

    Occurs in the mitochondrial matrix, requires acetyl-CoA, produces CO2, NADH, FADH2, and ATP.

  • Electron transport chain: location, ATPase and hydrogen ion pump

    Located in the inner mitochondrial membrane, uses NADH and FADH2 to pump H+ ions and drive ATP synthesis via ATP synthase.

  • Oxaloacetate

    A four-carbon molecule that combines with acetyl-CoA to form citrate in the citric acid cycle.

  • Ketone bodies, broken down

    Produced from fatty acids in the liver and broken down in peripheral tissues for energy during fasting.

  • Urea

    A nitrogenous waste product formed in the liver from ammonia during protein catabolism.

  • Glycogenesis

    The process of converting glucose to glycogen for storage in liver and muscle cells.

  • Gluconeogenesis

    Formation of glucose from non-carbohydrate sources like amino acids and glycerol.

  • Body’s stored energy versus immediate energy

    Stored energy is in glycogen and fat; immediate energy comes from glucose and ATP available in cells.

  • Hormones involved in blood glucose levels

    Include insulin (lowers glucose) and glucagon (raises glucose).

  • Hypothalamus

    Brain region that regulates hunger, thirst, body temperature, and metabolic rate.

  • Metabolic rate

    The rate at which the body uses energy, influenced by factors like thyroid hormones and activity.

  • Micronutrients

    Essential vitamins and minerals required in small amounts for enzyme function and metabolism.

  • Complete proteins

    Proteins containing all essential amino acids required by the body.

  • Vitamins

    Organic compounds needed in small amounts for metabolic reactions and maintaining health.

  • HDL versus LDL

    HDL transports cholesterol from tissues to liver; LDL delivers cholesterol to tissues, linked to atherosclerosis.

  • How are essential nutrients obtained

    Essential nutrients must be obtained from the diet because the body cannot synthesize them.