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Endocrine System and Hormonal Regulation

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  • Endocrine gland

    A gland that secretes hormones directly into the bloodstream to regulate body functions.

  • Hormone

    A chemical messenger secreted by endocrine glands that travels through the blood to target cells.

  • Target cell

    A cell that has specific receptors for a hormone and responds to its signal.

  • Receptor

    A protein on or inside a target cell that binds to a specific hormone to trigger a response.

  • Second messenger

    A molecule inside the cell that transmits signals from a hormone-receptor complex to trigger cellular responses.

  • cAMP

    Cyclic adenosine monophosphate, a common second messenger that activates protein kinases inside cells.

  • Protein kinase

    An enzyme that phosphorylates proteins, altering their activity in response to hormonal signals.

  • Phosphorylation

    The addition of a phosphate group to a protein, often regulating its function and activity.

  • Negative feedback

    A regulatory mechanism where the output of a process inhibits its own production to maintain homeostasis.

  • Humoral stimulus

    Hormone release triggered by changes in blood levels of ions or nutrients.

  • Neural stimulus

    Hormone release triggered by nerve impulses.

  • Hormonal stimulus

    Hormone release triggered by another hormone.

  • Pituitary gland

    The master endocrine gland that controls other endocrine glands and regulates growth and metabolism.

  • Hypothalamus

    A brain region that controls the pituitary gland and links the nervous system to the endocrine system.

  • Thyroid gland

    An endocrine gland that produces hormones regulating metabolism, such as thyroxine (T₄) and triiodothyronine (T₃).

  • Parathyroid gland

    Small glands located behind the thyroid that regulate calcium levels by secreting parathyroid hormone (PTH).

  • Calcitonin

    A hormone from the thyroid that lowers blood calcium levels by inhibiting bone resorption.

  • Parathyroid hormone (PTH)

    A hormone that increases blood calcium levels by stimulating bone resorption and calcium absorption.

  • Thyroxine (T₄)

    A thyroid hormone that regulates metabolism and is converted into the active form T₃ in tissues.

  • Triiodothyronine (T₃)

    The active thyroid hormone that influences metabolic rate and protein synthesis.

  • Lipid-soluble hormone

    A hormone that can cross cell membranes and bind to intracellular receptors, often affecting gene expression.

  • Water-soluble hormone

    A hormone that cannot cross the cell membrane and binds to surface receptors, triggering second messenger pathways.

  • Up-regulation

    An increase in receptor number on target cells, making them more sensitive to a hormone.

  • Down-regulation

    A decrease in receptor number on target cells, reducing their sensitivity to a hormone.

  • Permissiveness

    When one hormone enhances the effect of another hormone on a target cell.

  • Synergism

    When two hormones produce a greater combined effect than the sum of their separate effects.

  • Antagonism

    When one hormone opposes or inhibits the action of another hormone.

  • Homeostasis

    The maintenance of a stable internal environment despite external changes, often regulated by hormones.