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Lymphatic, Immune, and Respiratory Systems - Anatomy & Physiology

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  • Major functions of the lymphatic system

    The lymphatic system returns interstitial fluid to the bloodstream, absorbs fats from the digestive tract, and participates in immune responses by housing lymphocytes.

  • Difference between whole blood, plasma, interstitial fluid, and lymph

    Whole blood contains cells and plasma; plasma is the fluid portion of blood; interstitial fluid bathes tissue cells; lymph is interstitial fluid collected into lymphatic vessels.

  • Structure and function differences between lymphatic vessels and blood vessels

    Lymphatic vessels have thinner walls, more valves, and carry lymph unidirectionally; blood vessels carry blood under pressure and have thicker walls.

  • Path of lymph circulation

    Lymph flows from lymphatic capillaries → larger lymphatic vessels → lymph nodes → lymph trunks → lymph ducts → subclavian veins.

  • Innate vs. adaptive immunity

    Innate immunity is nonspecific, immediate defense; adaptive immunity is specific, slower, and has memory.

  • Surface membrane barriers in innate immunity

    Include skin and mucous membranes with physical, chemical, and microbiological defenses like acidic pH, enzymes, and normal flora.

  • Phagocytosis steps

    Recognition and attachment, engulfment, formation of phagosome, fusion with lysosome, digestion, and exocytosis of debris.

  • Role of natural killer (NK) cells

    NK cells destroy virus-infected and tumor cells by inducing apoptosis without prior sensitization.

  • Complement system function

    Complement proteins enhance inflammation, opsonize pathogens, and form membrane attack complexes to lyse cells.

  • Inflammation causes and benefits

    Caused by tissue injury or infection; benefits include isolating pathogens, removing debris, and promoting healing.

  • Fever mechanism and benefits

    Pyrogens reset hypothalamic thermostat to raise body temperature, which inhibits pathogens and enhances immune function.

  • Antibody-mediated vs. cell-mediated immunity

    Antibody-mediated uses B cells and antibodies; cell-mediated uses T cells to destroy infected or abnormal cells.

  • Definition of antigen and self-antigen

    An antigen triggers immune response; a self-antigen is a normal body molecule recognized as self to prevent autoimmunity.

  • Major histocompatibility complex (MHC) classes and locations

    Class I MHC found on all nucleated cells; Class II MHC on antigen-presenting cells; both present antigens to T cells.

  • Immunocompetence and self-tolerance

    Immunocompetence is the ability of lymphocytes to recognize specific antigens; self-tolerance prevents immune attack on self.

  • Clonal selection process

    Antigen activates specific lymphocyte clone, which proliferates into effector and memory cells for targeted immunity.

  • Antibody structure

    Y-shaped molecule with two heavy and two light chains; variable regions bind antigen; constant region determines class and function.

  • Active vs. passive immunity

    Active immunity results from exposure to antigen; passive immunity is transfer of antibodies from another source.

  • Major functions of the respiratory system

    Includes ventilation, pulmonary gas exchange, gas transport in blood, and tissue gas exchange.

  • Conducting vs. respiratory zones of respiratory tract

    Conducting zone transports air; respiratory zone is where gas exchange occurs (alveoli).

  • Anatomical divisions of upper and lower respiratory tract

    Upper: nose, nasal cavity, pharynx; Lower: larynx, trachea, bronchi, lungs.

  • Functions of the larynx

    Protects airway, produces sound, and routes air and food into proper channels.

  • Differences between vestibular and vocal folds

    Vestibular folds protect airway; vocal folds produce sound by vibrating during exhalation.

  • Structure and function of the trachea

    Flexible tube with C-shaped hyaline cartilage rings that keep airway open and allow esophageal expansion.

  • Bronchi vs. bronchioles

    Bronchi have cartilage and glands; bronchioles lack cartilage and have smooth muscle to regulate airflow.

  • Respiratory membrane function

    Thin barrier between alveolar air and blood for efficient gas exchange.

  • Pulmonary ventilation definition

    Movement of air into and out of lungs; includes inspiration and expiration.

  • Boyle's Law and ventilation

    Gas pressure inversely related to volume; lung volume changes cause air to flow in or out.

  • Pulmonary volumes and capacities

    Include tidal volume, inspiratory reserve volume, expiratory reserve volume, residual volume, and capacities like vital capacity.

  • Dalton's Law of partial pressures

    Total pressure of gas mixture equals sum of partial pressures of individual gases.