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Muscle Tissue and Contraction - Anatomy & Physiology

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  • Four main characteristics of muscle tissue

    Excitability, contractility, extensibility, and elasticity.

  • Four main functions of muscle

    Movement, posture maintenance, joint stabilization, and heat generation.

  • Gross anatomy of muscle connective tissue sheaths

    Epimysium surrounds the whole muscle, perimysium surrounds fascicles, and endomysium surrounds individual muscle fibers.

  • Sliding filament model of muscle contraction

    Actin filaments slide past myosin filaments, shortening the sarcomere and causing contraction.

  • Neuromuscular junction

    Synapse where a motor neuron communicates with a skeletal muscle fiber using neurotransmitters.

  • Role of the Na+/K+ pump in muscle cells

    Maintains resting membrane potential by pumping 3 Na+ out and 2 K+ in, keeping the cell polarized.

  • Four steps of skeletal muscle contraction

    1. Excitation, 2. Excitation-contraction coupling, 3. Contraction (cross-bridge cycling), 4. Relaxation.

  • Cross Bridge Cycle

    Myosin heads bind to actin, pivot to pull filaments, release with ATP, and reset to repeat contraction.

  • ATP role in muscle contraction

    Provides energy for myosin head detachment and re-cocking during cross-bridge cycling.

  • Definition of involuntary muscle

    Muscle controlled without conscious effort, e.g., smooth and cardiac muscle.

  • Definition of voluntary muscle

    Muscle controlled consciously, e.g., skeletal muscle.

  • Definition of contraction in muscle tissue

    Activation of cross-bridges to generate tension and shorten muscle fibers.

  • Neurotransmitter at the neuromuscular junction

    Acetylcholine (ACh) is released to stimulate muscle fiber contraction.

  • Synaptic cleft

    Small gap between the motor neuron and muscle fiber where neurotransmitters are released.

  • Voltage-gated channel

    Ion channel that opens in response to changes in membrane potential.

  • Chemical-gated channel

    Ion channel that opens when a specific chemical (neurotransmitter) binds to it.

  • Polarized muscle cell membrane

    State where the inside of the cell is negatively charged relative to the outside.

  • Depolarization

    Loss of membrane potential as Na+ ions enter the cell, making it more positive.

  • Repolarization

    Restoration of the resting membrane potential by K+ ions leaving the cell.

  • Actin

    Thin filament protein that binds with myosin during contraction.

  • Myosin

    Thick filament protein with heads that form cross-bridges with actin.

  • Tropomyosin

    Protein that blocks myosin-binding sites on actin when muscle is relaxed.

  • Troponin

    Protein that binds calcium and moves tropomyosin to expose binding sites on actin.