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Respiratory System - Anatomy & Physiology

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  • Primary functions of the respiratory system

    Oxygen and carbon dioxide exchange, protection of respiratory surfaces from dehydration, temperature changes and pathogens, sound production for communication, and detection of odors by olfactory receptors.

  • Anatomical divisions of the respiratory system

    Upper respiratory system: nose, nasal cavity, sinuses, pharynx.
    Lower respiratory system: larynx, trachea, bronchus, lungs (bronchioles and alveoli).

  • Role of respiratory mucosa

    Mucous membrane lining nasal cavity, pharynx, larynx, trachea, bronchi, and bronchioles that traps debris and pathogens, protecting delicate exchange surfaces.

  • Functions of the nose in respiration

    Provides airway for breathing, moistens and warms air, filters inhaled air, serves as resonating chamber for speech, and houses olfactory receptors.

  • Purpose of nasal conchae

    Bony protrusions covered in thick mucus that increase surface area to warm, humidify, and filter incoming air.

  • Divisions of the pharynx

    Nasopharynx, oropharynx, and laryngopharynx; shared passageway for respiratory and digestive tracts.

  • Structure and function of the larynx

    Cartilaginous tube called the voice box containing vocal cords responsible for sound production and the glottis which controls air passage and phonation.

  • What is the glottis?

    The vocal cords plus the opening between them in the larynx; controls airflow and sound production by opening and closing.

  • How is sound produced in the larynx?

    Air passes through the open glottis, vibrating the elastic vocal folds; pitch depends on diameter, length, and tension of vocal cords.

  • Cartilages forming the larynx

    Thyroid cartilage (Adam's apple), cricoid cartilage, and epiglottis which prevents food from entering the respiratory tract during swallowing.

  • Function of the trachea

    Tough, flexible tube supported by cartilaginous rings that conducts air to the lungs and prevents collapse or overexpansion during pressure changes.

  • What is the carina of the trachea?

    A ridge of cartilage at the point where the trachea divides into left and right main bronchi.

  • Lung lobes and protection

    Right lung has 3 lobes (superior, middle, inferior); left lung has 2 lobes (superior, inferior). Both lungs are protected by the pleural cavity with parietal and visceral pleura.

  • Bronchial tree branching sequence

    Trachea → primary (main) bronchi → secondary (lobar) bronchi → tertiary (segmental) bronchi → bronchioles → terminal bronchioles → respiratory bronchioles → alveoli.

  • Function of alveoli

    Small air sacs covered by capillaries where gas exchange occurs between air and blood.

  • Components of the blood-air barrier

    Alveolar cell layer, fused basement membrane, and capillary endothelial layer; allows efficient gas exchange.

  • Effect of pneumonia on the respiratory system

    Inflammation causes fluid leakage into alveoli, compromising the blood-air barrier and reducing gas exchange efficiency.

  • Autonomic nervous system control of bronchioles

    Sympathetic activation causes bronchodilation (enlargement), parasympathetic activation causes bronchoconstriction (narrowing).

  • Three integrated steps of respiration

    1. Breathing (pulmonary ventilation)
    2. Gas diffusion across blood-air barrier
    3. Transport of O2 and CO2 between alveoli and blood.

  • Muscles involved in inspiration

    Diaphragm contracts downward and external intercostal muscles elevate the ribcage, increasing thoracic cavity volume to draw air in.

  • Mechanics of exhalation

    Diaphragm and external intercostal muscles relax, decreasing thoracic cavity volume and pushing air out; usually a passive process.

  • Normal respiratory rate in adults and children

    Adults: 12-18 breaths per minute; children: 18-20 breaths per minute.

  • Brain centers controlling respiration

    Respiratory centers in the medulla oblongata stimulate diaphragm and external intercostal muscles to regulate breathing.

  • Role of chemoreceptors in respiration

    Monitor blood O2, CO2, and pH levels; increased CO2 triggers increased respiratory rate to expel excess CO2.

  • Baroreceptor reflex effect on respiration

    High blood pressure decreases respiratory rate; low blood pressure increases respiratory rate.

  • Function of stretch receptors in lungs

    Prevent overexpansion of lungs during forced inhalation by triggering reflex inhibition of inspiration.

  • Protective respiratory reflexes

    Coughing and sneezing involve apnea (temporary suspension of breathing) to expel irritants from airways.

  • Age-related changes in the respiratory system

    Decreased lung capacity due to elastic tissue deterioration, arthritic rib joints restricting chest movement, and some emphysema is normal after age 50.

  • Emphysema and its effects

    Chronic destruction of alveolar surfaces reduces gas exchange area, causing shortness of breath and reduced exercise tolerance; linked to smoking and aging.

  • Pulmonary embolism

    Blockage of pulmonary artery by a traveling blood clot causing sudden shortness of breath and chest pain; often treated with blood thinners.

  • Difference between hypoxia and anoxia

    Hypoxia is low tissue oxygen levels; anoxia is complete oxygen deprivation causing rapid cell death.