What is the correct sequence of events following ligand binding in the Phosphoinositide Signaling Pathway?

• A. Ligand binding, GPCR conformational change, G protein activation, effector enzyme activation
• B. GPCR conformational change, ligand binding, effector enzyme activation, G protein activation
• C. Ligand binding, G protein activation, GPCR conformational change, effector enzyme activation
• D. Effector enzyme activation, ligand binding, GPCR conformational change, G protein activation

Answer: (A)