Analyze the interaction between PIP3 and PKB/PDK1 in insulin signaling.

• A. PIP3 directly phosphorylates PKB and PDK1, activating them.
• B. PIP3 binds to PKB and PDK1, leading to their activation and subsequent signaling.
• C. PIP3 is converted back to PIP2, which then activates PKB and PDK1.
• D. PIP3 inhibits PKB and PDK1, preventing their activation.

Answer: (B)