A mutation causes a change in the orientation of R groups in an alpha helix. How might this affect the protein's stability?

• A. The protein's stability would likely increase due to decreased steric hindrance.
• B. The protein's stability would increase due to additional hydrogen bonding.
• C. The protein's stability would likely decrease due to increased steric hindrance.
• D. The protein's stability would remain unchanged as R group orientation is irrelevant.

Answer: (C)