How does positive cooperativity affect substrate binding in the sequential model?

• A. Positive cooperativity has no effect on substrate binding.
• B. Binding of a substrate to one subunit increases the likelihood of neighboring subunits transitioning to the R state.
• C. Binding of a substrate to one subunit decreases the likelihood of neighboring subunits transitioning to the R state.
• D. Positive cooperativity only affects the T state.