What are the products of PIP2 cleavage by phospholipase C, and what is the role of each product?

• A. Both DAG and IP3 remain in the membrane to activate protein kinase C.
• B. DAG remains in the membrane and activates protein kinase C, while IP3 diffuses into the cell to release calcium.
• C. Both DAG and IP3 diffuse into the cell to release calcium.
• D. DAG diffuses into the cell to release calcium, while IP3 remains in the membrane and activates protein kinase C.

Answer: (B)