How do changes in enzyme state and substrate binding as substrate concentration increases lead to a higher reaction velocity?

• A. Increased substrate concentration traps more enzymes in the T state, reducing substrate binding and reaction velocity.
• B. Increased substrate concentration traps more enzymes in the R state, enhancing substrate binding and reaction velocity.
• C. Increased substrate concentration causes random changes in enzyme state and reaction velocity.
• D. Increased substrate concentration has no effect on enzyme state or reaction velocity.

Answer: (B)