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Determining Net Charge of a Peptide

4. Protein Structure / Determining Net Charge of a Peptide / Problem 5

Problem 5

Calculate the net charge of a peptide at pH 7.4 with the following ionizable groups: N-terminus (pKa 9.0), lysine side chain (pKa 10.5), and C-terminus (pKa 3.0).

A

-1

B

+1

C

+2

D

0