Evaluate the impact of PI3K activity on the insulin signaling pathway.

• A. PI3K activity inhibits the conversion of PIP2 to PIP3, blocking the signaling pathway.
• B. PI3K activity is crucial for converting PIP2 to PIP3, which is essential for downstream activation of PKB.
• C. PI3K activity has no effect on the insulin signaling pathway.
• D. PI3K activity degrades PIP2, preventing the formation of PIP3.

Answer: (B)