If Ki' is significantly larger than Ki, what does this suggest about the inhibitor's binding preference?

• A. The inhibitor prefers binding to the free enzyme over the enzyme-substrate complex.
• B. The inhibitor does not bind to either the free enzyme or the enzyme-substrate complex.
• C. The inhibitor binds equally to both the free enzyme and the enzyme-substrate complex.
• D. The inhibitor prefers binding to the enzyme-substrate complex over the free enzyme.

Answer: (A)