Biochemistry
What is the role of inositol 1,4,5-triphosphate (IP3) in the Phosphoinositide Signaling Pathway?
A mutation in phospholipase C (PLC) prevents it from hydrolyzing PIP2. What would be the expected consequence in the signaling pathway?
How does the G protein alpha subunit inactivate itself in the Phosphoinositide Signaling Pathway?
A patient has a mutation that causes overactivation of the Gq protein in the PSP pathway. What potential cellular response might you expect?
In a cell with a defective IP3 receptor, what would be the expected impact on calcium signaling?
How does diacylglycerol (DAG) contribute to the activation of protein kinase C (PKC) in the Phosphoinositide Signaling Pathway?
What are the immediate products of PIP2 hydrolysis by phospholipase C in the PSP pathway?
