Analyze the impact of proton pump inhibitors on gastric acid secretion.

• A. Proton pump inhibitors have no effect on gastric acid secretion.
• B. Proton pump inhibitors facilitate passive diffusion of protons.
• C. Proton pump inhibitors increase gastric acid secretion by enhancing proton gradients.
• D. Proton pump inhibitors reduce gastric acid secretion by blocking the creation of proton gradients.

Answer: (D)