Given the rate constants k1, k-1, and k2, how is the Michaelis constant (Km) calculated under steady state conditions?

• A. Km = k1 / (k-1 + k2)
• B. Km = k1 * k2 / k-1
• C. Km = k1 + k2 - k-1
• D. Km = (k-1 + k2) / k1

Answer: (D)