Biochemistry
In a scenario where the GDP to GTP exchange in the stimulatory G protein is inhibited, what would be the immediate consequence in the signaling pathway?
Analyze the effect of a mutation that prevents the dissociation of the G protein alpha subunit from the beta gamma subunits. How would this affect the signaling pathway?
Evaluate the impact of PKA activation on cellular metabolism during the fight or flight response.
Evaluate the importance of the conformational change in the beta adrenergic GPCR for the overall signaling pathway.
If adenylate cyclase is inhibited, what would be the effect on cyclic AMP production and subsequent cellular responses?
Synthesize the process of GTP hydrolysis with the reassembly of the G protein subunits to explain signal termination.
Evaluate the importance of the signaling cycle in maintaining cellular homeostasis.