Question 1

Which of the following best describes the Central Dogma of Molecular Biology?

Accepted Answer

It states that information flows from DNA to RNA to protein, but not from protein to nucleic acid.

Question 2

Which of the following is NOT one of the four major classes of biomolecules found in cells?

Accepted Answer

Steroids

Question 3

Which of the following statements about non-covalent interactions is TRUE?

Accepted Answer

They are individually weak but collectively can stabilize large biomolecular structures.

Question 4

Which equation correctly represents the force between two ions in an aqueous environment according to Coulomb’s law?

Accepted Answer

$$F = \frac{k q_1$ q_2$}{r^2$}$$

Question 5

Which of the following best explains why hydrophobic interactions occur in aqueous solutions?

Accepted Answer

They minimize the number of ordered water molecules, increasing the entropy of the system.

Question 6

Which of the following functional groups is commonly found in amino acids?

Accepted Answer

Amino group ($$-NH_2$)

Question 7

Which of the following bonds is the strongest under physiological conditions?

Accepted Answer

Covalent bond

Question 8

Which of the following is a polymer of amino acids?

Accepted Answer

Protein

Question 9

Which of the following best describes a hydrogen bond?

Accepted Answer

An interaction between a hydrogen atom covalently bonded to an electronegative atom and another electronegative atom.

Question 10

Which of the following is a correct example of a sequence-structure-function relationship in biochemistry?

Accepted Answer

A specific amino acid sequence determines the 3D structure of a protein, which in turn determines its function.

Question 11

Which of the following is a real-world example of the importance of understanding biochemistry at the molecular level?

Accepted Answer

The development of gene therapies for sickle cell disease using CRISPR technology.

Question 12

Which of the following statements about van der Waals interactions is TRUE?

Accepted Answer

They are weak interactions that occur due to transient fluctuations in electron clouds.

Question 13

Which of the following best describes the effect of the environment on ion pair (salt bridge) interactions in proteins?

Accepted Answer

Ion pairs are stronger in the interior of proteins, which is less polar than water.

Question 14

Which of the following is the correct order of bond strength from strongest to weakest?

Accepted Answer

Covalent \u003e Hydrogen bond \u003e van der Waals

Question 15

Which of the following is a consequence of the crowded environment inside cells?

Accepted Answer

Macromolecules are at high effective concentrations, leading to frequent intermolecular interactions.

Question 16

Which of the following is a correct statement about the hydrophobic effect?

Accepted Answer

It is driven by the increase in entropy as water molecules are released from ordered cages around nonpolar groups.

Question 17

Which of the following is a correct example of a macromolecule and its monomer?

Accepted Answer

Polysaccharide – Monosaccharide

Question 18

Which of the following is a key reason why non-covalent interactions are important in biological systems?

Accepted Answer

They allow for transient and reversible interactions necessary for dynamic cellular processes.

Biochemistry I: Introduction, Biochemical Terminology, and Non-Covalent Interactions

Study Guide - Practice Questions