Question 1

Which of the following is produced from the conversion of one mole of acetyl-CoA to two moles of CO$_2$ in the citric acid cycle?

Accepted Answer

3 moles of NADH

Question 2

The reaction in the Citric Acid Cycle most similar to pyruvate dehydrogenase involves which enzyme?

Accepted Answer

Alpha-ketoglutarate dehydrogenase

Question 3

Which reaction in the Citric Acid Cycle produces a GTP molecule?

Accepted Answer

Conversion of succinyl-CoA to succinate

Question 4

Which Citric Acid Cycle intermediate is considered a product?

Accepted Answer

Citrate

Question 5

How many moles of ATP are produced from three moles of carbon dioxide by pyruvate dehydrogenase and Citric Acid Cycle processes, assuming 1 mole of FADH$_2$ and 3 moles of NADH are generated?

Accepted Answer

$11$

Question 6

Which of the following is NOT a function of the glycolysis pathway?

Accepted Answer

Production of FADH$_2$

Question 7

During the Citric Acid Cycle, which step involves substrate-level phosphorylation?

Accepted Answer

Conversion of succinyl-CoA to succinate

Question 8

Which enzyme catalyzes the formation of citrate from oxaloacetate and acetyl-CoA?

Accepted Answer

Citrate synthase

Question 9

What is the net ATP yield from one molecule of glucose after glycolysis and the Citric Acid Cycle, assuming aerobic conditions?

Accepted Answer

$30$-$32$

Question 10

Which of the following statements about the Citric Acid Cycle is TRUE?

Accepted Answer

It generates reduced electron carriers for the electron transport chain.

Question 11

Which molecule is regenerated at the end of the Citric Acid Cycle to allow the cycle to continue?

Accepted Answer

Oxaloacetate

Question 12

Which of the following is a key regulatory enzyme in glycolysis?

Accepted Answer

Phosphofructokinase-1

Question 13

A patient with a deficiency in succinate dehydrogenase would most likely have impaired production of which molecule?

Accepted Answer

Fumarate

Question 14

Which step in the Citric Acid Cycle involves the release of CO$_2$?

Accepted Answer

Conversion of isocitrate to alpha-ketoglutarate

Question 15

Which molecule is NOT an intermediate of the Citric Acid Cycle?

Accepted Answer

Glucose

Question 16

Which of the following best describes the role of NAD$^+$ in the Citric Acid Cycle?

Accepted Answer

It acts as an oxidizing agent, accepting electrons during oxidation reactions.

Question 17

Which enzyme is responsible for the conversion of malate to oxaloacetate in the Citric Acid Cycle?

Accepted Answer

Malate dehydrogenase

Question 18

In the Citric Acid Cycle, which step is most similar to the pyruvate dehydrogenase reaction?

Accepted Answer

Conversion of alpha-ketoglutarate to succinyl-CoA

Question 19

Which of the following is a direct product of glycolysis?

Accepted Answer

Pyruvate

Question 20

Which of the following is a biosynthetic precursor produced by glycolysis?

Accepted Answer

3-phosphoglycerate

Citric Acid Cycle: Practice Questions and Key Concepts

Study Guide - Practice Questions

Study Guide - Flashcards