Q: Which of the following is FALSE regarding the sodium-potassium ATPase mechanism?

It pumps 3 Na\textsuperscript{+} ions into the cell.

Q: Which of the following correctly lists the order of steps for the sodium-potassium ATPase mechanism?

I. 3 Na\textsuperscript{+} ions bind, II. ATP hydrolysis, III. Conformational change releasing 3 Na\textsuperscript{+} ions outside the cell, IV. 2 K\textsuperscript{+} ions bind, V. Conformational change releasing 2 K\textsuperscript{+} ions inside the cell.

Q: Which equation best represents the overall reaction catalyzed by the sodium-potassium ATPase?

$2 \mathrm{K}^{+}_{\text{out}} + 3 \mathrm{Na}^{+}_{\text{in}} + \mathrm{ATP} \rightarrow 2 \mathrm{K}^{+}_{\text{in}} + 3 \mathrm{Na}^{+}_{\text{out}} + \mathrm{ADP} + \mathrm{P}_{i}$

Q: A patient is found to have a mutation that impairs ATP binding to the sodium-potassium ATPase. What is the most likely consequence?

The pump will be unable to transport Na\textsuperscript{+} and K\textsuperscript{+} ions across the membrane.

Q: If the sodium-potassium pump is inhibited by a toxin, what immediate effect would you expect on the cell?

An increase in intracellular Na\textsuperscript{+} and a decrease in intracellular K\textsuperscript{+}.

Question 1

Which of the following best describes the type of transport performed by the sodium-potassium ATPase?

Accepted Answer

Active transport through an antiporter.

Question 2

What is the primary function of the sodium-potassium pump in maintaining cellular homeostasis?

Accepted Answer

It creates a transmembrane potential that is more negative on the inside and more positive on the outside.

Question 3

Which of the following is FALSE regarding the sodium-potassium ATPase mechanism?

Accepted Answer

It pumps 3 Na	extsuperscript{+} ions into the cell.

Question 4

Which of the following correctly lists the order of steps for the sodium-potassium ATPase mechanism?

Accepted Answer

I. 3 Na	extsuperscript{+} ions bind, II. ATP hydrolysis, III. Conformational change releasing 3 Na	extsuperscript{+} ions outside the cell, IV. 2 K	extsuperscript{+} ions bind, V. Conformational change releasing 2 K	extsuperscript{+} ions inside the cell.

Question 5

What is the net effect of the sodium-potassium pump on the charge distribution across the plasma membrane?

Accepted Answer

It makes the inside of the cell more negative than the outside.

Question 6

Which equation best represents the overall reaction catalyzed by the sodium-potassium ATPase?

Accepted Answer

$2 \mathrm{K}^{+}_{	ext{out}} + 3 \mathrm{Na}^{+}_{	ext{in}} + \mathrm{ATP} ightarrow 2 \mathrm{K}^{+}_{	ext{in}} + 3 \mathrm{Na}^{+}_{	ext{out}} + \mathrm{ADP} + \mathrm{P}_{i}$

Question 7

Why is the sodium-potassium pump considered an example of primary active transport?

Accepted Answer

It uses the energy from the hydrolysis of ATP to move ions against their concentration gradients.

Question 8

A patient is found to have a mutation that impairs ATP binding to the sodium-potassium ATPase. What is the most likely consequence?

Accepted Answer

The pump will be unable to transport Na	extsuperscript{+} and K	extsuperscript{+} ions across the membrane.

Question 9

Which of the following best explains why the sodium-potassium pump is essential for nerve impulse transmission?

Accepted Answer

It maintains the resting membrane potential required for action potential generation.

Question 10

If the sodium-potassium pump is inhibited by a toxin, what immediate effect would you expect on the cell?

Accepted Answer

An increase in intracellular Na	extsuperscript{+} and a decrease in intracellular K	extsuperscript{+}.

Question 11

Which of the following statements about the sodium-potassium pump is correct?

Accepted Answer

It moves Na	extsuperscript{+} out of the cell and K	extsuperscript{+} into the cell.

Question 12

Which step in the sodium-potassium pump cycle directly requires ATP hydrolysis?

Accepted Answer

Conformational change that releases Na	extsuperscript{+} ions outside the cell.

Question 13

Which of the following best describes the role of phosphorylation in the sodium-potassium pump mechanism?

Accepted Answer

Phosphorylation causes a conformational change that releases Na	extsuperscript{+} ions outside the cell.

Question 14

Which of the following is a direct consequence of the sodium-potassium pump activity in animal cells?

Accepted Answer

Generation of a membrane potential.

Question 15

A researcher adds a non-hydrolyzable ATP analog to a cell. What effect will this have on the sodium-potassium pump?

Accepted Answer

The pump will bind ATP but will not undergo the conformational change needed to transport ions.

Sodium-Potassium Ion Pump: Mechanism and Function

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