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General Biology I - Cell Division and Genetics

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  • Compare asexual and sexual reproduction

    Asexual reproduction involves one parent and produces genetically identical offspring. Sexual reproduction involves two parents and produces genetically diverse offspring through meiosis and fertilization.

  • Structure of duplicated and unduplicated chromosomes

    An unduplicated chromosome is a single DNA molecule. A duplicated chromosome consists of two sister chromatids joined at the centromere.

  • Stages of the cell cycle

    The cell cycle includes interphase (G1, S, G2 phases) where the cell grows and DNA replicates, followed by the mitotic phase (M phase) where mitosis and cytokinesis occur.

  • Phases of mitosis and key events

    Prophase: chromosomes condense, spindle forms.
    Prometaphase: nuclear envelope breaks down, spindle attaches.
    Metaphase: chromosomes align at the metaphase plate.
    Anaphase: sister chromatids separate.
    Telophase: nuclear envelopes reform, chromosomes decondense.

  • Compare cytokinesis in animal and plant cells

    In animal cells, cytokinesis occurs by cleavage furrow formation. In plant cells, a cell plate forms to divide the cell.

  • How cancerous cells differ from healthy cells

    Cancer cells exhibit uncontrolled growth, ignore density-dependent inhibition and anchorage dependence, and can invade other tissues (metastasis).

  • Functions of mitosis

    Mitosis enables growth, tissue repair, and asexual reproduction by producing genetically identical somatic cells.

  • How chromosomes are paired

    Chromosomes are paired as homologous chromosomes, one from each parent, carrying genes for the same traits at corresponding loci.

  • Distinguish somatic cells and gametes

    Somatic cells are diploid body cells with paired chromosomes. Gametes are haploid reproductive cells with a single set of chromosomes.

  • Why sexual reproduction requires meiosis

    Meiosis reduces chromosome number by half to produce haploid gametes, ensuring chromosome number is restored at fertilization.

  • Phases of meiosis I and meiosis II

    Meiosis I: Prophase I (crossing over), Metaphase I, Anaphase I (homologs separate), Telophase I.
    Meiosis II: Prophase II, Metaphase II, Anaphase II (sister chromatids separate), Telophase II.

  • Compare mitosis and meiosis

    Mitosis produces two identical diploid cells for growth. Meiosis produces four genetically diverse haploid cells for sexual reproduction.

  • How genetic variation is produced in sexual reproduction

    Genetic variation arises from crossing over during prophase I and independent assortment of chromosomes during metaphase I of meiosis.

  • Distinguish genetic diseases and chromosomal disorders

    Genetic diseases result from mutations in specific genes. Chromosomal disorders result from changes in chromosome number or structure.

  • Main types of chromosomal changes

    Types include deletion, duplication, inversion, and translocation.

  • Why cancer is not usually inherited

    Cancer usually results from mutations acquired during life, not inherited mutations in germ cells.

  • Definition of anaphase

    Anaphase is the mitotic phase when sister chromatids separate and move toward opposite poles.

  • What is anchorage dependence

    Anchorage dependence is the requirement that cells must be attached to a surface to divide.

  • Define binary fission

    Binary fission is an asexual reproduction method in prokaryotes where the cell divides into two identical cells.

  • What is a centromere

    The centromere is the region where sister chromatids are joined and where spindle fibers attach during mitosis.

  • Role of centrosomes

    Centrosomes organize the mitotic spindle fibers that separate chromosomes during mitosis.

  • What is a chiasma

    A chiasma is the site where crossing over occurs between homologous chromosomes during prophase I of meiosis.

  • Define cleavage furrow

    The cleavage furrow is the indentation that begins cytokinesis in animal cells.

  • What is a clone

    A clone is a group of genetically identical individuals produced by asexual reproduction.

  • What is crossing over

    Crossing over is the exchange of genetic material between homologous chromosomes during meiosis, increasing genetic variation.

  • Define density-dependent inhibition

    Density-dependent inhibition is the phenomenon where crowded cells stop dividing.

  • Difference between diploid and haploid

    Diploid cells have two sets of chromosomes; haploid cells have one set.

  • What is a karyotype

    A karyotype is an ordered display of an organism's chromosomes used to detect chromosomal abnormalities.