Which of the following best describes the process of nitric oxide signaling?

• A. Nitric oxide is actively transported into the cell and binds to nuclear receptors.
• B. Nitric oxide diffuses across the plasma membrane and binds to intracellular signaling proteins.
• C. Nitric oxide is endocytosed and then binds to cytoplasmic proteins.
• D. Nitric oxide binds to extracellular receptors to initiate signaling.

Answer: (B)