Which of the following is a key difference between the ubiquitin-proteasome pathway and the lysosomal pathway?

• A. The ubiquitin-proteasome pathway occurs in the lysosome, while the lysosomal pathway occurs in the cytoplasm.
• B. The lysosomal pathway requires ATP, while the ubiquitin-proteasome pathway does not.
• C. The lysosomal pathway is specific to eukaryotic cells, while the ubiquitin-proteasome pathway is not.
• D. The ubiquitin-proteasome pathway requires ubiquitin tagging, while the lysosomal pathway does not.

Answer: (D)