How do Type I and Type II topoisomerases differ in their mechanisms?

• A. Both Type I and Type II topoisomerases make double-strand breaks.
• B. Both Type I and Type II topoisomerases make single-strand breaks.
• C. Type I topoisomerases make single-strand breaks, while Type II make double-strand breaks.
• D. Type I topoisomerases make double-strand breaks, while Type II make single-strand breaks.

Answer: (C)