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Types of Enzyme Inhibition

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Terms in this set (4)

  • Competitive Inhibition

    Inhibitor resembles the substrate and competes for the same binding site on the enzyme

    Km increases and Vmax stays unchanged

    competes with substrate for same location

  • Noncompetitive Inhibition

    Inhibitor binds to site other than the active site, causing a change in enzyme configuration

    Vmax increases, Km unchanged

    doesn't want substrate at all, influences conformation of enzyme so substrate can't fit

  • Uncompetitive Inhibition

    Inhibitor binds only to the enzyme substrate complex, not to the free enzyme

    Vmax decreases and Km decreases

    doesn't compete for same site, inhibitor blocks product from coming out

  • Irreversible Inhibition

    Inhibitor covalently modifies the enzyme, rendering it permanently inactive (suicide inhibitor)

    binds to enzyme, both get stuck together, enzyme can never work again