Question 1

Which hormone is primarily responsible for stimulating the production and maturation of megakaryocytes, leading to platelet formation?

Accepted Answer

Thrombopoietin

Question 2

Platelets are kept inactive and mobile in the bloodstream by which two substances released from endothelial cells?

Accepted Answer

Nitric oxide (NO) and prostacyclin

Question 3

During the process of hemostasis, which step involves the exposure of collagen fibers and the formation of a platelet plug?

Accepted Answer

Platelet plug formation

Question 4

A patient presents with petechiae and widespread hemorrhage due to a deficiency in circulating platelets. What is the most likely diagnosis?

Accepted Answer

Thrombocytopenia

Question 5

Which clotting factors require vitamin K for their synthesis in the liver?

Accepted Answer

Factors II, VII, IX, X

Question 6

Aspirin inhibits the formation of which molecule, thereby reducing platelet aggregation?

Accepted Answer

Thromboxane A$$_2$$

Question 7

Which enzyme is responsible for crosslinking fibrin during the final stages of coagulation?

Accepted Answer

Transglutaminase (Factor XIII)

Question 8

A thrombus that breaks free and travels through the bloodstream is called a(n):

Accepted Answer

Embolus

Question 9

Which inherited disorder is most commonly associated with a deficiency in von Willebrand factor?

Accepted Answer

Von Willebrand disease

Question 10

Which of the following drugs directly inhibits thrombin to prevent clot formation?

Accepted Answer

Dabigatran

Question 11

A patient with liver cirrhosis is at increased risk for bleeding because:

Accepted Answer

The liver cannot produce bile, impairing fat and vitamin K absorption needed for clotting factor synthesis.

Question 12

Which process removes unneeded clots after healing by converting plasminogen to plasmin?

Accepted Answer

Fibrinolysis

Question 13

Which feedback mechanism is involved in platelet plug formation?

Accepted Answer

Positive feedback loop

Question 14

A patient is diagnosed with Hemophilia B. Which clotting factor is deficient?

Accepted Answer

Factor IX

Question 15

Which of the following is the correct sequence of events in hemostasis?

Accepted Answer

Vascular spasm → Platelet plug formation → Coagulation

Question 16

Which plasma protein acts as a 'glue' to help platelets adhere to exposed collagen fibers during vessel injury?

Accepted Answer

Von Willebrand factor

Question 17

Which of the following best describes the role of platelet-derived growth factor (PDGF) during vessel healing?

Accepted Answer

Stimulates cell division of smooth muscle cells and fibroblasts to rebuild the vessel wall

Question 18

If a patient is treated with warfarin, which step in the clotting cascade is most directly affected?

Accepted Answer

Synthesis of vitamin K-dependent clotting factors

Question 19

Which of the following equations correctly represents the conversion of fibrinogen to fibrin during coagulation?

Accepted Answer

$$\mathrm{Fibrinogen} \xrightarrow{\mathrm{Thrombin}} \mathrm{Fibrin}$$

Question 20

A patient with deep vein thrombosis is at risk for which life-threatening complication if the clot dislodges?

Accepted Answer

Pulmonary embolism

Lecture #8

Guida di studio - Domande di pratica