Q: Which of the following equations correctly represents the net reaction of glycolysis?

$$ \text{Glucose} + 2 \text{NAD}^+ + 2 \text{ADP} + 2 \text{P}_i \rightarrow 2 \text{Pyruvate} + 2 \text{NADH} + 2 \text{ATP} + 2 \text{H}_2\text{O} + 2 \text{H}^+ $$

Question 1

Which enzyme catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate in glycolysis?

Accepted Answer

Phosphoglucose isomerase

Question 2

During glycolysis, which step is considered the committed and rate-limiting step?

Accepted Answer

Conversion of fructose-6-phosphate to fructose-1,6-bisphosphate

Question 3

Which of the following enzymes is allosterically inhibited by ATP and citrate, and activated by AMP and fructose-2,6-bisphosphate?

Accepted Answer

Phosphofructokinase-1

Question 4

A patient presents with a deficiency in pyruvate kinase. Which of the following is the most likely consequence?

Accepted Answer

Hemolytic anemia due to decreased ATP in erythrocytes

Question 5

Which of the following best describes the role of NAD+ in glycolysis?

Accepted Answer

Acts as an electron acceptor during the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate

Question 6

Which of the following equations correctly represents the net reaction of glycolysis?

Accepted Answer

$$ 	ext{Glucose} + 2 	ext{NAD}^+ + 2 	ext{ADP} + 2 	ext{P}_i ightarrow 2 	ext{Pyruvate} + 2 	ext{NADH} + 2 	ext{ATP} + 2 	ext{H}_2	ext{O} + 2 	ext{H}^+ $$

Question 7

Which enzyme is responsible for the substrate-level phosphorylation that produces ATP in the final step of glycolysis?

Accepted Answer

Pyruvate kinase

Question 8

Which of the following best explains why erythrocytes rely exclusively on glycolysis for ATP production?

Accepted Answer

They lack mitochondria

Question 9

A mutation causes phosphofructokinase-1 to lose its sensitivity to ATP inhibition. What is the most likely metabolic consequence?

Accepted Answer

Uncontrolled glycolysis and excessive ATP production

Question 10

Which of the following statements about the regulation of glycolysis is correct?

Accepted Answer

Pyruvate kinase is activated by fructose-1,6-bisphosphate

Question 11

Which of the following is a direct product of the reaction catalyzed by aldolase in glycolysis?

Accepted Answer

Glyceraldehyde-3-phosphate and dihydroxyacetone phosphate

Question 12

In a patient with lactic acidosis, which glycolytic enzyme is most likely functioning at an increased rate?

Accepted Answer

Lactate dehydrogenase

Question 13

Which of the following best describes the fate of NADH produced in glycolysis under anaerobic conditions?

Accepted Answer

It is used to reduce pyruvate to lactate

Question 14

Which glycolytic intermediate is a substrate for both glycolysis and the pentose phosphate pathway?

Accepted Answer

Glucose-6-phosphate

Question 15

Which of the following best explains why glycolysis is considered an ancient metabolic pathway?

Accepted Answer

It occurs in the cytoplasm and does not require organelles

Microbial Model Organisms in Biochemistry

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