Question 1

Which of the following best describes the role of platelets in primary hemostasis?

Accepted Answer

They form a temporary plug by adhering to the site of vascular injury.

Question 2

A patient presents with excessive bleeding after minor injuries. Laboratory tests reveal a platelet count of $$80 	imes 10^9$/L. $$Which term best describes this condition?

Accepted Answer

Thrombocytopenia

Question 3

Which coagulation factor is NOT found in the bloodstream but is instead found in tissues and is essential for the extrinsic pathway?

Accepted Answer

Factor III (Tissue thromboplastin)

Question 4

A deficiency in which coagulation factor is associated with hemophilia B?

Accepted Answer

Factor IX

Question 5

Which laboratory test is most appropriate for monitoring the effectiveness of warfarin (Coumadin) therapy?

Accepted Answer

Prothrombin time (PT) and International Normalized Ratio (INR)

Question 6

During the intrinsic pathway of coagulation, which factor is the first to be activated upon exposure to collagen from a damaged blood vessel?

Accepted Answer

Factor XII

Question 7

Which of the following drugs acts by inhibiting platelet aggregation rather than directly affecting coagulation factors?

Accepted Answer

Aspirin

Question 8

A patient with a deficiency in von Willebrand factor (vWF) would most likely have a problem with which aspect of hemostasis?

Accepted Answer

Platelet adhesion to subendothelial surfaces

Question 9

Which of the following best explains why a deficiency in Factor XII does NOT typically result in abnormal bleeding?

Accepted Answer

Factor XII deficiency does not impair the formation of a stable fibrin clot in vivo.

Question 10

Which of the following is the correct sequence of events in the formation of a stable blood clot following vessel injury?

Accepted Answer

Platelet plug formation → Fibrin clot formation → Clot retraction

Question 11

Which of the following statements about the common pathway of coagulation is correct?

Accepted Answer

It is initiated by the conversion of prothrombin to thrombin by Factor Xa.

Question 12

A patient is found to have a prolonged APTT but a normal PT. Which of the following factor deficiencies is most likely?

Accepted Answer

Factor IX

Question 13

Which of the following best describes the function of plasmin in the hemostatic process?

Accepted Answer

It breaks down fibrin clots during fibrinolysis.

Question 14

Which of the following is a vitamin K-dependent coagulation factor?

Accepted Answer

Factor II (Prothrombin)

Question 15

A patient with a genetic deficiency in Factor VIII would most likely present with which clinical condition?

Accepted Answer

Hemophilia A

Question 16

Which of the following best explains the role of Platelet Factor 3 (PF3) in coagulation?

Accepted Answer

PF3 is a phospholipid on the platelet membrane that provides a surface for coagulation factor activation.

Question 17

Which of the following is the main inhibitor of thrombin in the coagulation cascade?

Accepted Answer

Antithrombin II

Question 18

A patient is being treated with heparin. Which laboratory test should be used to monitor the effectiveness of this therapy?

Accepted Answer

Activated partial thromboplastin time (APTT)

Question 19

Which of the following best describes the function of Factor XIII in the coagulation cascade?

Accepted Answer

It stabilizes the fibrin clot by cross-linking fibrin strands.

Question 20

A trauma patient is found to have a deficiency in high-molecular-weight kininogen (HMWK). Which pathway of coagulation is most likely to be affected?

Accepted Answer

Intrinsic pathway

Overview of Hemostasis and Blood Coagulation

Guida di studio - Domande di pratica

Study guide - Flashcard