Scelta multipla
Multiple origins of replication on the DNA molecules of eukaryotic cells serve to:
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8. DNA Replication
Overview of DNA Replication
Scelta multipla
In DNA replication, which enzyme unwinds ("unzips") the double helix by breaking hydrogen bonds to prepare the DNA template strands for replication?
A
DNA ligase
B
Primase
C
Helicase
D
DNA polymerase III
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Understand the role of each enzyme listed in the problem in the context of DNA replication.
Recall that DNA replication begins with the separation of the two strands of the DNA double helix to expose the template strands.
Identify the enzyme responsible for breaking the hydrogen bonds between complementary base pairs, effectively 'unzipping' the DNA strands.
Recognize that DNA ligase is involved later in replication, joining Okazaki fragments on the lagging strand.
Note that primase synthesizes RNA primers, and DNA polymerase III extends the new DNA strand, but neither unwinds the DNA.
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