$$\text{INR} = \text{PR}^{\text{ISI}}$$

Question 1

Which of the following best describes the role of healthy endothelium in haemostasis?

Accepted Answer

It produces prostacyclin (PGI2) and nitric oxide (NO) to inhibit platelet activation.

Question 2

A patient presents with thrombocytopenia and large platelets. Which congenital disorder is most likely?

Accepted Answer

Bernard-Soulier syndrome

Question 3

Which of the following is NOT a typical cause of acquired qualitative platelet defects?

Accepted Answer

Congenital mutations

Question 4

In the cell-based model of coagulation, which step is primarily responsible for the large-scale production of thrombin?

Accepted Answer

Propagation

Question 5

Which laboratory test is most sensitive to deficiencies in the extrinsic pathway of coagulation?

Accepted Answer

Prothrombin Time (PT)

Question 6

A patient with a prolonged APTT but normal PT is most likely to have a deficiency in which factor?

Accepted Answer

Factor VIII

Question 7

Which of the following statements about fibrinolysis is correct?

Accepted Answer

Plasminogen is activated by tissue plasminogen activator (t-PA) and urokinase (u-PA).

Question 8

Which equation correctly represents the calculation of the International Normalised Ratio (INR)?

Accepted Answer

$$	ext{INR} = 	ext{PR}^{	ext{ISI}}$$

Question 9

Which factor deficiency is associated with spontaneous intracranial bleeds and delayed wound healing?

Accepted Answer

Factor XIII

Question 10

A patient with liver disease is likely to have an increased Prothrombin Time (PT) due to:

Accepted Answer

Decreased synthesis of extrinsic coagulation factors

Question 11

Which of the following is a contraindication for platelet transfusion?

Accepted Answer

Thrombotic thrombocytopenic purpura (TTP)

Question 12

Which of the following drugs inhibits the vitamin K-dependent posttranslational modification of coagulation factors?

Accepted Answer

Warfarin

Question 13

A patient with a deficiency in protein C or S is at increased risk for:

Accepted Answer

Venous thrombosis

Question 14

Which of the following is the main pathway for initiation of coagulation?

Accepted Answer

Extrinsic pathway

Question 15

Which of the following statements about the Clauss fibrinogen assay is correct?

Accepted Answer

It measures clotting time as a function of fibrinogen concentration.

Question 16

Which factor is NOT included in adsorbed plasma used for correction tests?

Accepted Answer

Factor IX

Question 17

Which of the following is a rare autosomal recessive disorder found around the Mediterranean Sea, involving combined deficiency of FV and FVIII?

Accepted Answer

Combined FV and FVIII deficiency

Question 18

Which of the following is a direct oral anticoagulant that inhibits thrombin?

Accepted Answer

Dabigatran

Question 19

Which of the following statements about the mechanical coagulometer (KC1 Delta) is correct?

Accepted Answer

It uses a ball bearing to detect clot formation.

Question 20

Which of the following is a common complication in severe Haemophilia A due to repeated hemarthroses?

Accepted Answer

Joint destruction

Disorders of Haemostasis and Laboratory Investigation

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