what-factor-contributes-to-the-irreversibility-of-a-nucleophilic-attack-on-an-al

Question

What factor contributes to the irreversibility of a nucleophilic attack on an alkylated phosphate anhydride?

Accepted Answer

Formation of a stable pyrophosphate ion

Answer

High temperature conditions

Answer

Presence of a weak nucleophile

Answer

Use of a non-polar solvent