Nucleophilic Acyl Substitution

22. Carboxylic Acid Derivatives: NAS / Nucleophilic Acyl Substitution – The Three Rules / Problema 7

Problema 7

Show how to synthesize each of the compounds below using appropriate acyl chlorides and alcohols as the starting materials.
(i) methyl propionate
(ii) phenyl 2-methylhexanoate

Synthesis of methyl propionate using acyl chloride and methanol.

Synthesis of phenyl 2-methylhexanoate using acyl chloride and phenol.

Synthesis of methyl propionate using acyl chloride and methanol.

Synthesis of phenyl 2-methylhexanoate using acyl chloride and alcohol.

Show how to synthesize each of the compounds below using appropriate acyl chlorides and alcohols as the starting materials.(i) methyl propionate(ii) phenyl 2-methylhexanoate