Question 1

Which of the following carboxylic acid derivatives is the most reactive toward nucleophilic acyl substitution?

Accepted Answer

Acid halide ($$RCOX)$$

Question 2

What is the correct IUPAC name for the following compound: $$CH_3COCl$$?

Accepted Answer

Acetyl chloride

Question 3

Which of the following statements best explains why amides are less reactive than esters in nucleophilic acyl substitution?

Accepted Answer

Amides have a less polarized carbonyl due to resonance donation from nitrogen.

Question 4

Which of the following is the correct order of reactivity for carboxylic acid derivatives toward nucleophilic acyl substitution (most to least reactive)?

Accepted Answer

Acid halide \u003e acid anhydride \u003e ester \u003e amide

Question 5

Which functional group has the highest priority for naming complex molecules according to IUPAC rules?

Accepted Answer

Carboxylic acid ($$RCOOH)$$

Question 6

What is the product when an acid chloride reacts with water?

Accepted Answer

Carboxylic acid ($$RCOOH)$$

Question 7

Which of the following best describes the mechanism of nucleophilic acyl substitution?

Accepted Answer

Addition of nucleophile to the carbonyl carbon followed by elimination of the leaving group.

Question 8

Which of the following is a correct name for the compound $$CH_3COOCH_2CH_3$$?

Accepted Answer

Ethyl acetate

Question 9

Why can you convert an acid chloride to an amide, but not the reverse under normal conditions?

Accepted Answer

Because acid chlorides are more reactive than amides.

Question 10

Which of the following functional groups has the lowest priority for naming complex molecules?

Accepted Answer

Alkyne ($$C \equiv C)$$

Question 11

A chemist wants to synthesize an ester from a carboxylic acid derivative. Which reagent should they use?

Accepted Answer

Alcohol ($$R'OH)$$

Question 12

Which of the following is the correct name for the compound $$CH_3CONHCH_3$$?

Accepted Answer

N-methylacetamide

Question 13

Which of the following best explains why acid anhydrides are more reactive than esters?

Accepted Answer

The leaving group in anhydrides is a resonance-stabilized carboxylate ion.

Question 14

Which of the following is a correct product of the reaction between an acid chloride and ammonia ($$NH_3$$)?

Accepted Answer

Amide ($$RCONH_2)$$

Question 15

Which of the following functional groups is directly converted to a carboxylic acid upon hydrolysis?

Accepted Answer

Acid halide ($$RCOX)$$

Question 16

A student wants to synthesize an amide from an ester. Which reagent should they use?

Accepted Answer

Amine ($$R'NH_2$)

Question 17

Which of the following is the correct name for the compound $$CH_3COOCOCH_3$$?

Accepted Answer

Acetic anhydride

Question 18

Which of the following best describes the effect of electron-withdrawing groups on the reactivity of carboxylic acid derivatives?

Accepted Answer

They increase the reactivity by making the carbonyl carbon more electrophilic.

Question 19

Which of the following is a correct product of the reaction between an acid anhydride and an alcohol?

Accepted Answer

Ester ($$RCOOR')$$

Question 20

Which of the following functional groups is NOT considered a carboxylic acid derivative?

Accepted Answer

Aldehyde ($$RCHO)$$

Carboxylic Acid Derivatives and Nucleophilic Acyl Substitution

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