Question 1

Which of the following substituents, when attached to the α-carbon of acetic acid, will most significantly increase its acidity due to the inductive effect?

Accepted Answer

-F

Question 2

Why is trichloroacetic acid much more acidic than acetic acid?

Accepted Answer

Because multiple chlorine atoms increase the inductive electron-withdrawing effect, stabilizing the carboxylate anion.

Question 3

Which acid will have the lowest pK$$_a$$ value among the following?

Accepted Answer

$$\mathrm{Cl_3CCOOH}$$

Question 4

In aromatic carboxylic acids, which position of a nitro group ($$\mathrm{-NO_2$}) $$will result in the greatest increase in acidity?

Accepted Answer

Ortho position

Question 5

Which of the following statements best explains why benzenesulphonic acid is a strong acid?

Accepted Answer

It has a highly stable sulfonate anion due to charge delocalization.

Question 6

Which of the following drugs is used as a primary agent for the treatment of epileptic seizures and contains a cyclic imide structure?

Accepted Answer

Ethosuximide

Question 7

What is the main reason barbiturates are acidic?

Accepted Answer

Mesomeric effect due to charge delocalization in the anion

Question 8

Which of the following reactions is used to convert a carboxylic acid to an acid chloride?

Accepted Answer

$$\mathrm{RCOOH + $$SOCl_2$$ \rightarrow RCOCl + SO_2$ + HCl}$$

Question 9

Which of the following statements about the reduction of carboxylic acids is correct?

Accepted Answer

Carboxylic acids can be reduced to alcohols using $$\mathrm{$$LiAlH_4$$}.$$

Question 10

Which of the following is a correct example of Fischer esterification?

Accepted Answer

$$\mathrm{C_6H_5COOH + CH_3OH \xrightarrow{HCl,\,heat} C_6H_5COOCH_3 + H_2O}$$

Question 11

Which of the following groups will decrease the acidity of a benzoic acid derivative?

Accepted Answer

-OH

Question 12

Why are carboxylic acid salts often used in drug formulations?

Accepted Answer

They enhance the solubility of the drug in water.

Question 13

Which of the following compounds will undergo mesomeric effect?

Accepted Answer

Succinimide

Question 14

A patient is prescribed a sulphonamide antibiotic. What is the main chemical reason for its effectiveness?

Accepted Answer

It forms a stable anion due to resonance, allowing it to inhibit bacterial enzymes.

Question 15

Which of the following statements about the effect of substituent position on acidity is correct?

Accepted Answer

The closer the electron-withdrawing group is to the carboxyl group, the greater the acidity.

Question 16

Which of the following is the correct IUPAC name for the compound $$\mathrm{ClCH_2COOH}$$?

Accepted Answer

Chloroacetic acid

Question 17

Which of the following is a correct statement about the mesomeric effect in carboxylic acids?

Accepted Answer

It is due to resonance stabilization of the carboxylate anion.

Question 18

Which of the following is a correct example of a carboxylic acid salt used as a food preservative?

Accepted Answer

Sodium benzoate

Question 19

Which reagent is preferred for converting carboxylic acids to acid chlorides due to its gaseous by-products?

Accepted Answer

$$\mathrm{$$SOCl_2$$}$$

Carboxylic Acids & Their Derivatives: Acid Strength, Substituent Effects, and Key Reactions

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