Question 1

Which of the following best describes the role of isopropanol in the Meerwein–Ponndorf–Verley (MPV) reduction?

Accepted Answer

It serves as the hydride donor, reducing the carbonyl compound.

Question 2

In the MPV reduction, which metal complex is commonly used as a catalyst?

Accepted Answer

$$Al(OiPr)_3$$

Question 3

What is the main product when cyclohexanone undergoes MPV reduction with isopropanol and $$Al(OiPr)_3$$?

Accepted Answer

Cyclohexanol

Question 4

Which of the following statements about the MPV reduction mechanism is correct?

Accepted Answer

The hydride is transferred from the alpha carbon of isopropanol to the carbonyl carbon of the substrate.

Question 5

Which of the following is a byproduct of the MPV reduction when acetophenone is reduced with isopropanol?

Accepted Answer

Acetone

Question 6

A chemist wants to selectively reduce a ketone in the presence of an aldehyde. Which property of the MPV reduction makes it suitable for this transformation?

Accepted Answer

It is more selective for ketones over aldehydes.

Question 7

Which of the following best explains why $$Al(OiPr)_3 is $$used as a catalyst in the MPV reduction?

Accepted Answer

It coordinates to the carbonyl oxygen, activating it for hydride transfer.

Question 8

Which of the following is the correct balanced equation for the MPV reduction of benzophenone with isopropanol?

Accepted Answer

$$Ph_2CO + (CH_3$)_2CHOH \rightarrow Ph_2CHOH + (CH_3$)_2CO$$

Question 9

In the MPV reduction, what is the fate of the isopropanol molecule?

Accepted Answer

It is oxidized to acetone.

Question 10

Which of the following best describes the transition state of the MPV reduction?

Accepted Answer

A six-membered cyclic transition state involving aluminum, the carbonyl substrate, and isopropanol.

Question 11

A pharmaceutical company needs to reduce a ketone to an alcohol without affecting an alkene in the molecule. Why is the MPV reduction a good choice?

Accepted Answer

It selectively reduces ketones without affecting alkenes.

Question 12

Which of the following is NOT a typical feature of the MPV reduction?

Accepted Answer

Direct use of molecular hydrogen ($$H_2) as $$the reducing agent.

Question 13

Which of the following best describes the selectivity of the MPV reduction?

Accepted Answer

It is chemoselective for the reduction of ketones over aldehydes.

Question 14

Which of the following is a limitation of the MPV reduction?

Accepted Answer

It cannot reduce esters or carboxylic acids.

Question 15

In the MPV reduction, which step is considered the rate-determining step?

Accepted Answer

Hydride transfer from isopropanol to the carbonyl carbon.

Meerwein–Ponndorf–Verley Reduction: Mechanism and Applications

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