Question 1

Which of the following best describes the mechanism of the Grignard reaction when reacting phenylmagnesium bromide with formaldehyde?

Accepted Answer

A nucleophilic addition where the Grignard reagent acts as a nucleophile attacking the carbonyl carbon, followed by protonation.

Question 2

Which of the following compounds will undergo electrophilic aromatic substitution most rapidly?

Accepted Answer

Toluene

Question 3

What is the major product when benzene reacts with acetyl chloride ($$CH_3COCl) in $$the presence of $$AlCl_3$$?

Accepted Answer

Acetophenone

Question 4

Which of the following statements about carboxylic acids and their derivatives is correct?

Accepted Answer

Acid chlorides are more reactive than amides toward nucleophilic acyl substitution.

Question 5

A student mixes benzaldehyde with acetone and sodium hydroxide. Which reaction is most likely to occur?

Accepted Answer

Aldol condensation

Question 6

Which of the following best explains why $$NO_2 is a $$meta-directing group in electrophilic aromatic substitution?

Accepted Answer

It withdraws electron density from the ortho and para positions, making the meta position relatively more reactive.

Question 7

Which laboratory technique would be most appropriate for separating a mixture of benzoic acid and benzyl alcohol?

Accepted Answer

Acid-base extraction

Question 8

What is the expected product when ethyl acetate reacts with excess ammonia?

Accepted Answer

Acetamide

Question 9

Which of the following is the correct order of reactivity toward nucleophilic acyl substitution (most to least reactive)?

Accepted Answer

Acid chloride \u003e Anhydride \u003e Ester \u003e Amide

Question 10

A student observes a yellow precipitate when adding 2,4-dinitrophenylhydrazine (DNPH) to an unknown compound. What functional group is present?

Accepted Answer

Aldehyde or ketone

Question 11

Which of the following best describes the UV-visible absorption of benzene?

Accepted Answer

It arises from $$\pi \rightarrow \pi^*$$ electronic transitions.

Question 12

Which of the following is a correct statement about the Grignard reagent?

Accepted Answer

It is prepared by reacting an alkyl halide with magnesium in dry ether.

Question 13

Which of the following is the correct product of the reaction between benzene and bromine in the presence of $$FeBr_3$$?

Accepted Answer

Bromobenzene

Question 14

Which of the following statements about aromaticity is correct?

Accepted Answer

Aromatic compounds must be planar, cyclic, and follow Hückel's rule ($$4n+2$$ $$\pi$$ electrons).

Question 15

Which of the following best explains why tertiary alkyl halides undergo $$S_N1$$ reactions more readily than primary alkyl halides?

Accepted Answer

Tertiary alkyl halides form more stable carbocations due to hyperconjugation and inductive effects.

Question 16

Which of the following is the correct structure for the product of the reaction between acetic anhydride and ethanol?

Accepted Answer

Ethyl acetate and acetic acid

Question 17

A student is asked to synthesize methyl benzoate from benzoic acid. Which sequence of reagents would be most appropriate?

Accepted Answer

Methanol and sulfuric acid

Question 18

Which of the following is a correct statement about the effect of electron-donating groups on the reactivity of aromatic rings in electrophilic aromatic substitution?

Accepted Answer

They activate the ring and direct substitution to the ortho and para positions.

Question 19

Which of the following best describes the product of the reaction between benzaldehyde and 2,4-dinitrophenylhydrazine (DNPH)?

Accepted Answer

A hydrazone derivative

Organic Chemistry II and Laboratory – Syllabus and Course Structure (CHM 252)

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