why-is-ligand-binding-significant-in-the-initiation-of-gpcr-desensitization

Question

Why is ligand binding significant in the initiation of GPCR desensitization?

Accepted Answer

It triggers the phosphorylation of GPCRs by BARK.

Answer

It inhibits the phosphorylation of GPCRs by BARK.

Answer

It decreases the affinity of GPCRs for secondary messengers.

Answer

It increases the affinity of GPCRs for G proteins.